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Programmed death ligand 1 (PD-L1) has emerged as a biomarker that can help to predict responses to immunotherapies targeted against PD-L1 and its receptor (PD-1). Companion tests for evaluating PD-L1 expression as a biomarker of response have been developed for many cancer immunotherapy agents. These assays use a variety of detection platforms at different levels (protein, mRNA), employ diverse biopsy and surgical samples, and have disparate positivity cutoff points and scoring systems, all of which complicate the standardization of clinical decision-making. This review summarizes the current understanding and ongoing investigations regarding PD-L1 expression as a potential biomarker for clinical outcomes of anti-PD-1/PD-L1 immunotherapy.
Liu, D., Wang, S., & Bindeman, W. (2017). Clinical Applications of PD-L1 Bioassays for Cancer Immunotherapy. Journal of Hematology & Oncology, 10 (1), 110. https://doi.org/10.1186/s13045-017-0479-y
Originally published in Journal of Hematology & Oncology (2017) 10:110. The original material can be found here.
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