Acetaminophen Toxicity to the Liver

Authors

Sara Miriam Flaum

Abstract

Acetaminophen is a drug commonly used in America. Acetaminophen is an excellent antipyretic and has good analgesic effects, especially for a nonprescription drug. However, unlike other nonprescription drugs in this category, it can have significant liver toxicity. This paper discusses the potential for liver toxicity, and presents information on how acetaminophen affects specific proteins in the liver (P450). For example, not only can it inhibit drug metabolism via acting as an alternative (competitive) substrate for proteins that are responsible for drug metabolism, it can also paradoxically increase drug metabolism by increasing these proteins (induction of P450). The literature reviewed and presented suggests that there are significant risks and benefits associated with taking acetaminophen with other prescribed drugs and it would behoove patients to consult with their primary physician or caretaker prior to initiation of therapy.

Recommended Citation

Sara Miriam Flaum. (2007). Acetaminophen Toxicity to the Liver. The Science Journal of the Lander College of Arts and Sciences, 1(1), 1-13. Retrieved from https://touroscholar.touro.edu/sjlcas/vol1/iss1/2