The History of Thalidomide

Authors

Ilana Fakherian

Abstract

Thalidomide, introduced in Germany in 1954, was a drug that was initially prescribed for its sedative properties. In the late 1950s, thalidomide was widely used by women as an antiemetic drug to alleviate the nausea and vomiting (morning sickness) common in the early stages of pregnancy and to help them sleep. Thalidomide gained notoriety in 1961 when it was found to cause severe malformations in the growing fetus, such as stunted development or the complete absence of limbs. More over, later studies revealed that thalidomide generates peripheral neuropathy, dizziness, constipation, and menstruation abnormalities. However, at the time, inadequate tests were performed to assess the drug's safety. Unfortunately, more than 10,000 children were born with these disabling abnormalities before the drug was taken off the market. This disaster triggered more rigorous government regulations for drug testing.

Recommended Citation

Ilana Fakherian. (2007). The History of Thalidomide. The Science Journal of the Lander College of Arts and Sciences, 1(1), 55-69. Retrieved from https://touroscholar.touro.edu/sjlcas/vol1/iss1/6