The Science Journal of the Lander College of Arts and Sciences
Abstract
This paper will analyze an important study performed by Chung et al. (2018) regarding transforming growth factor-beta (TGFbeta), which plays an important role in various cellular processes. Paradoxically, TGF-beta plays a different role in the development of cancer at various points. In early-stage tumors, TGF-beta has been known to inhibit cancer growth, but in later stages, it acts as a cancer promoter. Chung et al. (2018) attempted to ascertain the efficaciousness of the drug Sorafenib in suppressing TGF-beta responses, as well as the ways that this drug achieves its goal and the implications that their findings may have for future research. The present paper is divided into three parts. The “Introduction” will detail the history of the research on TGF-beta; “Results” will delve into Chung et al.’s (2018) experiment; “Conclusion” will outline the study’s implications and will suggest directions for further study. The paper concludes that while Chung et al.’s (2018) work lends hope to the fight against cancer, it is not yet sufficient to definitively state that TGF-beta’s mechanisms can be effectively exploited for therapies.
Recommended Citation
Yosef Sonbolian. (2025). Friend and Foe: TGF-beta, Its Role in Tumor Development, and an Analysis of Chung et al. (2018). The Science Journal of the Lander College of Arts and Sciences, 18(2), 127-133. Retrieved from https://touroscholar.touro.edu/sjlcas/vol18/iss2/17
