The Science Journal of the Lander College of Arts and Sciences
Abstract
This research paper explores the potential of mesenchymal stem cells (MSCs) within the realm of dentistry, focusing particularly on their ability to repair tissues and regenerate entire teeth. MSCs are significant as they can send differentiation signals to nearby cells and release growth factors such as TGF-β and VEGF, which promote cellular activities necessary for dental repair and regeneration. The paper discusses the traditional methods of dental restoration, such as fillings and implants, and their inherent limitations. It then transitions to exploring innovative strategies that utilize MSCs to overcome these challenges and regenerate tooth structures including enamel, dentin, and periodontal ligaments. It examines two primary methods for regenerating teeth: the in vitro creation and transplantation of bioengineered tooth germs, and the in vivo development of these structures within a host organism. The study highlights significant breakthroughs and advancements with stem cells in the field of dentistry which are demonstrated by the successful regeneration of full tooth structures, including their roots. They also offer a future alternative to potentially replace conventional methods and treatments with ones that can naturally integrate and function within the mouth. The paper concludes with an analysis of the potential clinical applications and future directions for research in stem cell-mediated dental regeneration.
Recommended Citation
Akiva Goldschmidt. (2025). Implant Alternatives: The Advancements of Stem Cells in Regenerative Dentistry. The Science Journal of the Lander College of Arts and Sciences, 18(2), 134-138. Retrieved from https://touroscholar.touro.edu/sjlcas/vol18/iss2/18
