The Science Journal of the Lander College of Arts and Sciences
Abstract
The gastrointestinal (GI) system and the brain share a highly integrated relationship mediated by the gut–brain axis, with implications across a range of medical disciplines. Irritable bowel syndrome (IBS) is the most prevalent disorder of gut brain interaction (DGBI) which affects a significant portion of the global population, yet its pathophysiology has historically been poorly understood. This review examines the development and maintenance of IBS, drawing on literary sources to explore the gut–brain axis and disease expression which occurs as a result of its dysfunction. Common pathological features of IBS include visceral hypersensitivity, altered serotonin signaling, inappropriate immune activation, and abnormal gut motility. Associated psychiatric comorbidities and chronic pain disorders underscore CNS involvement. Therapeutic strategies include gut-directed pharmacology, neuromodulators, GI-psychology, and vagus nerve stimulation. A multilayered treatment approach informed by insight into the gut–brain axis may offer effective symptom relief. As the field of neurogastroenterology continues to evolve, expanded insight into the gut–brain axis will translate into more effective therapeutics for IBS and a wide range of related disorders.
Recommended Citation
Malky Weiss. (2025). The Role of the Gut–Brain Axis in Irritable Bowel Syndrome. The Science Journal of the Lander College of Arts and Sciences, 19(1), 48-55. Retrieved from https://touroscholar.touro.edu/sjlcas/vol19/iss1/7
