The Science Journal of the Lander College of Arts and Sciences
Abstract
Living kidney donation is the optimal long-term treatment for patients with end-stage renal disease (ESRD), also known as end-stage kidney disease (ESKD). However, it also raises concerns regarding the long-term health of donors. This paper explores the potential risks that living kidney donors (LKDs) may face, focusing on the potential development of ESRD and post-donation pregnancy risks, especially in relation to established ESRD risk factors such as hypertension and diabetes mellitus. It also examines the impact of genetic and familial predispositions, structural kidney changes, and proteinuria as contributors to future decline in kidney function. Concerns including reductions in erythropoietin (EPO) levels post-donation are discussed, highlighting EPO’s role in red blood cell (RBC) production. Post-donation pregnancy-associated risks, including gestational hypertension, preeclampsia, and diabetes, are also reviewed. While the overall prognosis for LKDs remains favorable, the paper underscores the need for continued research, personalized risk assessment, and post-donation follow-up care to ensure long-term donor safety.
Recommended Citation
Yehudis Fasten. (2025). What Are the Long-Term Health Implications of Living Kidney Donation?. The Science Journal of the Lander College of Arts and Sciences, 19(1), 56-63. Retrieved from https://touroscholar.touro.edu/sjlcas/vol19/iss1/8
