Cellular lipid oxidation is a known cause for the cascade leading to the formation of lipid laden foam cells, which can cause of atherosclerosis. While statins and antioxidants have recently come under question in the amelioration of atherosclerosis, Flavonoids have recently been touted as a powerful antioxidant and suppresser of atherosclerosis. This paper will attempt to show why statins and vitamin E have come under scrutiny, and how the desired effects of Flavonoids can be attributed to the role it plays in increased paraoxonase-1 activity (a known anti inflammatory associated with HDL), decreased C- Reactive protein activity, and increased nitric oxide (NO) in endothelial cells among other factors.
Lewis, Y. (2010). Atherosclerosis and Antioxidants. The Science Journal of the Lander College of Arts and Sciences, 3(1). Retrieved from https://touroscholar.touro.edu/sjlcas/vol3/iss1/7