The following is an excerpt from the introduction to this article: Ever since the discovery of bacteria and their role in the disease process in the mid-1800s, scientists have been heavily involved in the discovery and development of drug therapies and their mechanism of action in the human body. Shortly after the initial discovery came the era of drug discovery of the late 1800s-early 1900s, also known as the “drug revolution” (Dash and Cudworth 1998). Although the drug revolution led to the rapid discovery of many new drugs, pharmacological factors such as dosage forms, drug delivery systems, plasma drug levels, and how all these factors contribute to the efficacy of a drug were poorly understood. It wasn’t until the mid- 1900s that these factors were identified (Dash and Cudworth 1998). One particular factor which, once discovered, turned into a main focus in pharmacological research and lead to improvements in drug efficacy is centered on the importance of maintaining a steady therapeutic drug concentration level in the plasma.
Farkas, C. (2012). Modified-Release Drugs. The Science Journal of the Lander College of Arts and Sciences, 5 (2). Retrieved from https://touroscholar.touro.edu/cgi/viewcontent.cgi?article=1146&context=sjlcas