The Science Journal of the Lander College of Arts and Sciences


Allergic rhinitis and asthma are closely linked diseases which are very prevalent within the population, affecting millions. They are both characterized by chronic airway inflammation. They are often present in the same patients and rhinitis is even considered an independent risk factor for asthma. Treating allergic rhinitis can reduce the severity of asthma. Mechanisms connecting the two have been researched for many years. Studies show that they have a similar allergic mechanism that is mediated by the same cells. The allergic inflammation is characterized by the presence of eosinophils and is mediated by T-helper type 2 lymphocytes. The circulation of Th2 cells and the cytokines it releases, including IL-4 and IL-5, are important factors in airway inflammation. When their levels are reduced, the condition is improved. Controlling the production and circulation of these cells can potentially help treat allergic rhinitis and asthma.