Laron syndrome is a congenital autosomal recessive disorder that is caused by a mutation in the growth hormone receptor. People with this syndrome have an insensitivity to growth hormone. Insulin-like growth factor 1 is produced by the liver in response to GH stimulus. It is responsible for systemic GH activities. If there is something wrong with the growth hormone receptor there will be decreased levels of IGF-1. Low IGF-1 levels cause physical deformities notable short stature. Additionally, people with low levels of IGF-1 have a natural resistance to cancer. This article discusses the ways that the decreased levels of IGF-1 in Laron subjects protect the body from cancer.
Margolis, R. (2015). Why Are People With Laron Syndrome Immune to Cancer?. The Science Journal of the Lander College of Arts and Sciences, 9 (1). Retrieved from https://touroscholar.touro.edu/cgi/viewcontent.cgi?article=1043&context=sjlcas