BACKGROUND/OBJECTIVES: Advanced glycation end products (AGEs) contribute to the pathophysiology of lifestyle-related diseases. To identify nutrients associated with AGEs, this study explored the factors by investigating the relationship between nutrients changes and changes of blood AGEs during a weight loss program in obese women.
SUBJECTS/METHODS: Twenty-five obese women (age: 50 ± 8 years, body mass index: 28.7 ± 3.4 kg/m2 ) underwent a weight loss program with energy-restricted meal replacement for 2 months. Three-day weighted dietary records and blood tests including blood AGEs were performed at the baseline and after the 2-month intervention. Their correlation was examined during the intervention period.
RESULTS: The changes in AGEs were significantly and negatively correlated with those of intake levels of vitamin D (r = -0.54; P < 0.05).
CONCLUSION: Vitamin D might be a useful nutrient to reduce AGEs in obese women.
Sukino, S., Kotani, K., Nirengi, S., Gugliucci, A., Caccavello, R., Tsuzaki, K., . . . Sakane, N. (2016). Dietary intake of vitamin D is related to blood levels of advanced glycation end products during a weight loss program in obese women. Journal of Biomedicine, 1, 1-14.