Cardiovascular Sequelae of Sickle Cell Disease
Document Type
Article
Publication Date
1-1-2020
Journal Title
Cardiology in review
DOI
10.1097/CRD.0000000000000264
Abstract
Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathies worldwide. It is a multisystem disease that causes considerable patient morbidity. Despite advances in medical treatment, cardiopulmonary complications remain the most common cause of death in individuals with SCD. A growing body of evidence has shown that SCD results in a spectrum of cardiovascular complications through a variety of mechanisms, including chronic hemolysis, local tissue hypoxia, increased oxidative stress, and autonomic instability. Herein, we will examine the pathophysiology of sickle cell vasculopathy and discuss the spectrum of cardiovascular sequelae of the disease, while highlighting the impact of SCD on the cardiovascular health of the patients.
Recommended Citation
Aujla, A., Dutta, D., Amar, S., Frishman, W., & Lim, S. (2020). Cardiovascular Sequelae of Sickle Cell Disease. Cardiology in review, 28 (1), 10-13. https://doi.org/10.1097/CRD.0000000000000264
