The Outcomes of Solid Organ Transplant During COVID-19 Pandemic in The United States

Author Type(s)

Faculty, Resident/Fellow

Document Type

Abstract

Publication Date

2022

DOI

10.1111/ajt.16915

Journal Title

American Journal of Transplantation

Department

Medicine

Second Department

Surgery

Abstract

Introduction: COVID-19 has been pandemic in 2020, which impacts on solid organ transplantation (SOT) in US. The aim of this study was to analyze the outcomes of SOT during COVID-19 pandemic. Methods: WHO declared a pandemic on March 11th in 2020. We retrospectively analyzed data from UNOS regarding adult SOT outcomes between 2019-2021. We defined as pre-COVID period (March 11th 2019-March11th 2020) and COVID period (March 11th 2020- March 11th, 2021). Results: Overall, 5.5% fewer SOT were done during COVID period (36,311 vs 38,405, p<0.01). The number of SOT decreased in lung (-12.2%), pancreas (-7.8%) and kidney (-6.8%), but number of heart transplant increased (+2.9%). All SOT decreased in months of March-April 2020 with a rebound in numbers seen from May-July 2020. Living donor kidney transplant significantly decreased (p<0.01). The graft survival after SOT was inferior during COVID period in liver [HR(95%CI) 1.22 (1.06-1.40), p<0.01] and kidney [HR 1.29 (1.16-1.45), p<0.01], the other organs showed no difference. The overall survivals after SOT were inferior during COVID period in liver [HR 1.22(1.04-1.43), p=0.017] and kidney [HR 1.64(1.40-1.91), p<0.01] and the other organs showed no difference. For kidney transplant, the outcomes in deceased donor were inferior during COVID period (p<0.01), however, the outcomes in living donor showed no difference. Conclusions: During COVID period in US, overall SOT decreased except heart transplant, the outcome was inferior in liver and deceased donor kidney transplant, however the other organ showed similar outcomes.

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