SOX11 Is a Biomarker for Cyclin D1-Negative Mantle Cell Lymphoma

Authors

Roshni Narurkar, New York Medical College
Mohammad Alkayem, New York Medical College
Delong Liu, New York Medical CollegeFollow

DOI

10.1186/s40364-016-0060-9

Journal Title

Biomarker Research

First Page

6

Last Page

6

Document Type

Article

Publication Date

3-3-2016

Department

Medicine

Keywords

mantle cell lymphoma, SOX11 expression, hairy cell leukemia, SOX11 protein, small lymphocytic lymphoma, review

Disciplines

Medicine and Health Sciences

Abstract

Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and cyclin D1 protein but still had a gene expression profile suggesting a diagnosis of MCL. SOX11 expression was detected in most cyclin D1- negative MCL and can serve as a specific biomarker for the diagnosis of this subset of MCL. Lack of SOX11 expression in MCL was associated with an indolent subset and favorable prognosis.

Recommended Citation

Narurkar, R., Alkayem, M., & Liu, D. (2016). SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma. Biomarker Rsearch, 4, 6. doi:10.1186/s40364-016-0060-9

Publisher's Statement

Originally published in Biomarker Research. Licensed under CC-BY 4.0. https://doi.org/10.1186/s40364-016-0060-9