NYMC Faculty Publications
Kava Analogues as Agents for Treatment of Periodontal Diseases: Synthesis and Initial Biological Evaluation
DOI
10.1016/j.bmcl.2018.05.026
Journal Title
Bioorganic & Medicinal Chemistry Letters
First Page
2667
Last Page
2669
Document Type
Article
Publication Date
September 2018
Department
Pharmacology
Keywords
Benzoates, Cyclohexenes, Kava, Periodontal Diseases, Cyclohexene benzoate
Disciplines
Medicine and Health Sciences
Abstract
Six kava analogues of the structural type 3-oxocyclohex-1-en-1-yl benzoates (and corresponding benzamides) were synthesized and evaluated for their affect on periodontal deconstruction in collagen anti-body primed oral gavage model of periodontitis. The compounds were prepared through an acylation or amidation of the enolizable cyclic 1,3-diketone. We have learned that three of the analogues are responsible for the reduction of inflammatory cell counts within soft tissue. These novel kava-like molecules where the lactone is replaced by an alpha,beta-unsaturated ketone show promise in the prevention and treatment of inflammation and alveolar bone loss associated with periodontitis.
Recommended Citation
Cai, B., Panek, J., & Amar, S. (2018). Kava Analogues as Agents for Treatment of Periodontal Diseases: Synthesis and Initial Biological Evaluation. Bioorganic & Medicinal Chemistry Letters, 28 (16), 2667-2669. https://doi.org/10.1016/j.bmcl.2018.05.026
