NYMC Faculty Publications
Abdominal Fat Depots, Insulin Resistance, and Incident Diabetes Mellitus in Women With and Without HIV Infection
DOI
10.1097/QAD.0000000000001873
Journal Title
AIDS
First Page
1643
Last Page
1650
Document Type
Article
Publication Date
7-1-2018
Department
Epidemiology and Community Health
Abstract
OBJECTIVE: To determine the associations between visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) mass with homeostatic model assessment-insulin resistance (HOMA-IR) and incidence of diabetes mellitus in women with and without HIV infection. DESIGN: Cross-sectional design for associations between abdominal fat and HOMA-IR; longitudinal design for associations between abdominal fat and incident diabetes. METHODS: We assessed associations between dual X-ray absorptiometry scan-derived VAT and SAT with HOMA-IR in a subsample from the Women's Interagency HIV Study (n = 226 with and n = 100 without HIV) using linear regression. We evaluated associations of VAT, SAT, and HOMA-IR with incident diabetes mellitus using Cox proportional hazards models. RESULTS: VAT mass was positively associated with log HOMA-IR in fully adjusted linear regression models stratified by HIV serostatus, including adjustment for SAT. During median follow-up of 10.6 years, incidence of diabetes was 1.63 [95% CI 1.15, 2.31] and 1.32 [95% CI 0.77, 2.28] cases per 100 person-years in women with and without HIV (P = 0.52). In a fully adjusted model, baseline VAT (hazard ratio [HR] 2.64 per kg; 95% CI [1.14, 6.12]; P = 0.023) and SAT (HR 1.34 per kg; 95% CI [0.73, 2.45]; P = 0.35) were associated with incident diabetes but the latter was not statistically significant. CONCLUSIONS: VAT mass was independently associated with HOMA-IR in women with and without HIV and was independently associated with future development of diabetes.
Recommended Citation
Glesby, M., Hanna, D., Hoover, D., Shi, Q., Yin, M., Tien, P., Cohen, M., Anastos, K., & Sharma, A. (2018). Abdominal Fat Depots, Insulin Resistance, and Incident Diabetes Mellitus in Women With and Without HIV Infection. AIDS, 32 (12), 1643-1650. https://doi.org/10.1097/QAD.0000000000001873