NYMC Faculty Publications
NHL in Adolescents and Young Adults: A Unique Population
DOI
10.1002/pbc.27073
Journal Title
Pediatric Blood & Cancer
First Page
e27073
Document Type
Article
Publication Date
5-1-2018
Department
Pediatrics
Abstract
Non-Hodgkin lymphoma (NHL) is a heterogeneous group of lymphoid malignancies with high incidence in adolescents and young adults (AYAs). The most common diseases include diffuse large B-cell lymphoma, anaplastic large cell lymphoma, Burkitt lymphoma, lymphoblastic lymphoma, and primary mediastinal large B-cell lymphoma. In comparison to younger children and adults, AYAs (15-39 years) with NHL present a specific set of challenges including variations in tumor biology, inconsistent treatment, pharmacodynamics, and psychosocial barriers. While survival of AYAs with NHL has improved, cure rates remain suboptimal. Incorporation of novel agents into pediatric-inspired treatment regimens specifically designed for NHL in AYAs has led to improved outcomes. Consideration of AYAs as a distinct population in the diagnosis and treatment of NHL is encouraged.
Recommended Citation
Hochberg, J., Flower, A., Brugieres, L., & Cairo, M. (2018). NHL in Adolescents and Young Adults: A Unique Population. Pediatric Blood & Cancer, 65 (8), e27073. https://doi.org/10.1002/pbc.27073