NYMC Faculty Publications
Management of Psoriasis in Patients with Inflammatory Bowel Disease: From the Medical Board of the National Psoriasis Foundation
DOI
10.1016/j.jaad.2017.06.043
Journal Title
Journal of the American Academy of Dermatology
First Page
383
Last Page
394
Document Type
Article
Publication Date
February 2018
Department
Dermatology
Abstract
BACKGROUND: There is a significant association between psoriasis and inflammatory bowel disease (IBD). Many treatments for psoriasis and psoriatic arthritis are also used for IBD. OBJECTIVE: To assess therapeutic options for patients with psoriasis and concurrent IBD. METHODS: A systematic literature search was performed for clinical studies of biologic and systemic psoriasis medications in psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn's disease, for the period from January 1, 1947, to February 14, 2017. Randomized, controlled, double-blinded studies were selected if available. If not, the next highest level of available evidence was selected. RESULTS: Of the 2282 articles identified, 132 were selected. Infliximab and adalimumab have demonstrated efficacy in psoriasis, psoriatic arthritis, ulcerative; colitis, and Crohn's disease. Ustekinumab has demonstrated efficacy in psoriasis, psoriatic arthritis, and Crohn's disease. Certolizumab has demonstrated efficacy in psoriatic arthritis and Crohn's disease. Etanercept, secukinumab, brodalumab, and ixekizumab have demonstrated efficacy in psoriasis and psoriatic arthritis but may exacerbate or induce IBD. Guselkumab has demonstrated efficacy in psoriasis. LIMITATIONS: There are no known clinical trials of treatment specifically for concurrent psoriasis and IBD. CONCLUSIONS: Infliximab and adalimumab have demonstrated efficacy in psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn's disease; other agents have demonstrated efficacy for some, but not all, of these indications.
Recommended Citation
Whitlock, S., Enos, C., Armstrong, A., Gottlieb, A., Langley, R., Lebwohl, M., Merola, J., Ryan, C., Siegel, M., Weinberg, J., Wu, J., & Van Voorhees, A. (2018). Management of Psoriasis in Patients with Inflammatory Bowel Disease: From the Medical Board of the National Psoriasis Foundation. Journal of the American Academy of Dermatology, 78 (2), 383-394. https://doi.org/10.1016/j.jaad.2017.06.043