NYMC Faculty Publications
Acromegalic Cardiomyopathy: An Overview of Risk Factors, Clinical Manifestations, and Therapeutic Options
DOI
10.1097/CRD.0000000000000215
Journal Title
Cardiology in Review
First Page
307
Last Page
311
Document Type
Article
Publication Date
11-1-2018
Department
Medicine
Abstract
Acromegaly is a rare endocrine disorder that carries a significant burden of cardiovascular morbidity and mortality. Abnormalities of the growth hormone/insulin-like growth factor-1 axis in acromegaly lead to the characteristic CV manifestations of this disease. One hallmark feature of the disease is acromegalic cardiomyopathy, a syndrome of progressive cardiac dysfunction characterized by left ventricular hypertrophy, diastolic dysfunction, and combined systolic and diastolic dysfunction in the very advanced stage. In this article we review the current concepts regarding the pathophysiology of acromegalic cardiomyopathy and discuss the various risk factors for its development. We also explore the question of whether the alterations in cardiac function are reversible with successful biochemical control of growth hormone excess either medically or surgically.
Recommended Citation
Goldberg, M., Vadera, N., Yandrapalli, S., & Frishman, W. (2018). Acromegalic Cardiomyopathy: An Overview of Risk Factors, Clinical Manifestations, and Therapeutic Options. Cardiology in Review, 26 (6), 307-311. https://doi.org/10.1097/CRD.0000000000000215