NYMC Faculty Publications
DOI
10.1186/s40364-018-0121-3
Journal Title
Biomarker Research
First Page
7
Document Type
Article
Publication Date
2-1-2018
Department
Medicine
Abstract
Background: Myelodysplastic syndromes and acute myeloid leukemia usually occur sporadically in older adults. More recently cases of familial acute myeloid leukemia and/or myelodysplastic syndrome have been reported. Case presentation: Currently we report a father and son who both developed myelodysplastic syndrome that progressed to acute myeloid leukemia. Both patients were found to have the identical mutation of ASXL1 on nextgen sequencing of both hematologic and nonhematologic tissues. Conclusions: These cases support the diagnosis of a germline mutation of ASXL1.
Recommended Citation
Seiter, K., Htun, K., Baskind, P., & Liu, Z. (2018). Acute Myeloid Leukemia in a Father and Son with a Germline Mutation of ASXL1. Biomarker Research, 6, 7. https://doi.org/10.1186/s40364-018-0121-3
Publisher's Statement
Originally published in Biomarker Research, 2018, 6. The original material can be found here.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
