NYMC Faculty Publications
Cardiovascular Function in Male and Female JCR:LA-Cp Rats: Effect of High Fat/High Sucrose Diet
DOI
10.1152/ajpheart.00535.2016
Journal Title
American Journal of Physiology.Heart and Circulatory Physiology
First Page
H742
Last Page
H751
Document Type
Article
Publication Date
1-13-2017
Department
Pharmacology
Abstract
30% of the world population is diagnosed with metabolic syndrome. High fat/high sucrose diet (HF/HS, Western diet) correlates with metabolic syndrome prevalence. We characterized effects of the HF/HS diet on vascular (arterial stiffness, vasoreactivity, coronary collateral development) and cardiac (echocardiography) function, oxidative stress and inflammation in a rat model of metabolic syndrome (JCR). Furthermore, we determined whether male vs. female animals were affected differentially by the Western diet. Cardiovascular function in JCR male rats was impaired vs. normal rats (SD). HF/HS diet compromised cardiovascular (dys)function in JCR but not in SD male rats. In contrast, cardiovascular function was minimally impaired in JCR females on normal chow. However, cardiovascular function in JCR females on the HF/HS diet deteriorated to levels comparable to JCR males on the HF/HS diet. Similarly, oxidative stress was markedly increased in male but not female JCR rats on normal chow, but was equally exacerbated by the HF/HS diet in male and female JCR rats. These results indicate that the Western diet enhances oxidative stress and cardiovascular dysfunction in metabolic syndrome and eliminates the protective effect of female sex on cardiovascular function, implying that both males and females with metabolic syndrome are at equal risk for cardiovascular disease.
Recommended Citation
Hunter, I., Soler, A., Joseph, G., Hutcheson, B., Bradford, C., Zhang, F. F., & Rocic, P. (2017). Cardiovascular Function in Male and Female JCR:LA-Cp Rats: Effect of High Fat/High Sucrose Diet. American Journal of Physiology.Heart and Circulatory Physiology, 312 (4), H742-H751. https://doi.org/10.1152/ajpheart.00535.2016
Publisher's Statement
The original material can be found here: https://doi.org/10.1152/ajpheart.00535.2016
Comments
Please see the work itself for the complete list of authors.