NYMC Faculty Publications
Venetoclax and Low-Dose Cytarabine Induced Complete Remission in a Patient with High-Risk Acute Myeloid Leukemia: A Case Report
Journal Title
Frontiers of Medicine
First Page
593
Last Page
599
Document Type
Case Report
Publication Date
October 2018
Department
Medicine
Abstract
Conventional combination therapies have not resulted in considerable progress in the treatment of acute myeloid leukemia (AML). Elderly patients with AML and poor risk factors have grave prognosis. Midostaurin has been recently approved for the treatment of FLT-3-mutated AML. Venetoclax, a BCL-2 inhibitor, has been approved for the treatment of relapsed and/or refractory chronic lymphoid leukemia. Clinical trials on applying venetoclax in combination with cytarabine and other agents to treat various hematological malignancies are currently underway. Here, we present a case of a male patient with poor performance status and who developed AML following allogeneic hematopoietic stem cell transplant for high-risk myelodysplasia. The patient with high risk AML achieved complete response to the combined treatment regimen of low-dose cytarabine and venetoclax. Furthermore, we reviewed current clinical trials on the use of venetoclax for hematological malignancies.
Recommended Citation
Liu, B., Narurkar, R., Zafar, W., Song, Y., & Liu, D. (2018). Venetoclax and Low-Dose Cytarabine Induced Complete Remission in a Patient with High-Risk Acute Myeloid Leukemia: A Case Report. Frontiers of Medicine, 12 (5), 593-599. https://doi.org/10.1007/s11684-018-0635-y
