NYMC Faculty Publications
DOI
10.1055/s-0038-1660458
Journal Title
American Journal of Perinatology
First Page
1411
Last Page
1418
Document Type
Article
Publication Date
12-1-2018
Department
Pediatrics
Abstract
Objective: Anemia causes blood flow redistribution and altered tissue metabolic behavior to sustain homeostatic oxygen consumption. We hypothesized that anemia severity would correlate with increased regional fractional tissue oxygen extraction among premature neonates.
Study Design: Regional oxygen extraction was calculated using pulse oximetry and near-infrared spectroscopy data among neonates
Results: Twenty-seven neonates with gestational age 27 ± 2 weeks and birth weight 966 ± 181 g underwent 116 hematocrit determinations. Cerebral and flank oxygen extraction inversely correlated with hematocrit (cerebral r = −0.527, p = 0.005; flank r = −0.485, p = 0.01). Increased cerebral oxygen extraction was observed for the lowest three hematocrit quartiles (Q1 0.26 ± 0.08, p = 0.004; Q2 0.24 ± 0.09, p = 0.01; Q3 0.25 ± 0.09, p = 0.03; all compared with Q4 0.18 ± 0.10). Increased flank oxygen extraction occurred for the lowest two quartiles (Q1 0.36 ± 0.12, p < 0.001; Q2 0.35 ± 0.11, p < 0.001; compared with Q4 0.22 ± 0.13). Splanchnic oxygen extraction demonstrated no similar correlations.
Conclusion: Increases in tissue oxygen extraction may indicate early pathophysiologic responses to nascent anemia in premature neonates.
Recommended Citation
Mintzer, J., Parvez, B., & La Gamma, E. (2018). Regional Tissue Oxygen Extraction and Severity of Anemia in Very Low Birth Weight Neonates: A Pilot NIRS Analysis. American Journal of Perinatology, 35 (14), 1411-1418. https://doi.org/10.1055/s-0038-1660458
Publisher's Statement
This is the accepted manuscript version of this article. The final publication is available at Thieme via https://doi.org/10.1055/s-0038-1660458