NYMC Faculty Publications
Tuberculin-Active Carbohydrate That Induces Inhibition of Macrophage Migration but Not Lymphocyte Transformation
DOI
10.1126/science.170.3958.637
Journal Title
Science (New York, N.Y.)
First Page
637
Last Page
639
Document Type
Article
Publication Date
November 1970
Department
Pathology, Microbiology and Immunology
Keywords
Animals; Antigens; Cell Movement; Depression, Chemical; Guinea Pigs; Hypersensitivity, Delayed/etiology; In Vitro Techniques; Lymphocyte Activation; Macrophages/immunology; Mycobacterium bovis/immunology; Polysaccharides, Bacterial/pharmacology; Skin Tests; Tuberculin/analysis
Disciplines
Medicine and Health Sciences
Abstract
A tuberculin carbohydrate fraction, GAE, in sensitized animals induced a delayed type of skin reactivity and inhibited the migration of macrophages but failed to stimulate lymphocyte transformation in vitro. Tuberculin protein-containing fractions were active in each test. These results show that in vitro lymphocyte transformation is not necessarily a corollary of delayed type hypersensitivity.
Recommended Citation
Chaparas, S., Thor, D., Godfrey, H., Baer, H., & Hedrick, S. (1970). Tuberculin-Active Carbohydrate That Induces Inhibition of Macrophage Migration but Not Lymphocyte Transformation. Science (New York, N.Y.), 170 (3958), 637-639. https://doi.org/10.1126/science.170.3958.637
