Tuberculin-Active Carbohydrate That Induces Inhibition of Macrophage Migration but Not Lymphocyte Transformation

Authors

S Chaparas
D. E. Thor
Henry P. Godfrey, New York Medical CollegeFollow
Harold Baer
S. R. Hedrick

DOI

10.1126/science.170.3958.637

Journal Title

Science (New York, N.Y.)

First Page

637

Last Page

639

Document Type

Article

Publication Date

November 1970

Department

Pathology, Microbiology and Immunology

Abstract

A tuberculin carbohydrate fraction, GAE, in sensitized animals induced a delayed type of skin reactivity and inhibited the migration of macrophages but failed to stimulate lymphocyte transformation in vitro. Tuberculin protein-containing fractions were active in each test. These results show that in vitro lymphocyte transformation is not necessarily a corollary of delayed type hypersensitivity.

Recommended Citation

Chaparas, S., Thor, D., Godfrey, H., Baer, H., & Hedrick, S. (1970). Tuberculin-Active Carbohydrate That Induces Inhibition of Macrophage Migration but Not Lymphocyte Transformation. Science (New York, N.Y.), 170 (3958), 637-639. https://doi.org/10.1126/science.170.3958.637