NYMC Faculty Publications
Clonal Analysis of the T-cell Response of Mice to Herpes Simplex Virus: Correlation Between Lymphokine Production In Vitro and the Induction of Delayed-Type Hypersensitivity and Antiviral Activity In Vivo
Journal Title
Viral Immunology
First Page
35
Last Page
44
Document Type
Article
Publication Date
March 1987
Department
Pathology, Microbiology and Immunology
Abstract
The properties of two morphologically distinct L3T4+, Lyt2- "helper" T-cell clones specific for herpes simplex virus were investigated. Both of the clones produced IL-3 and interferon, but neither produced IL-2. Clone D6.6 produced macrophage agglutinating factor, a fibronectin-like lymphokine, and also a delayed hypersensitivity (DH) response when injected locally into syngeneic mice. Despite the presence of a DH producing clone and a non-DH producing clone, both were able to reduce the local virus titre to an equivalent degree. It is suggested that this protective activity is associated with the production of interferon-gamma. The significance of these results to mechanisms of protection against herpes simplex virus in vivo is discussed.
Recommended Citation
Seid, M., Leung, K., Pye, C., Phelan, J., Nash, A., & Godfrey, H. (1987). Clonal Analysis of the T-cell Response of Mice to Herpes Simplex Virus: Correlation Between Lymphokine Production In Vitro and the Induction of Delayed-Type Hypersensitivity and Antiviral Activity In Vivo. Viral Immunology, 1 (1), 35-44. https://doi.org/10.1089/vim.1987.1.35
