NYMC Faculty Publications
Title
Clonal Analysis of the T-cell Response of Mice to Herpes Simplex Virus: Correlation Between Lymphokine Production In Vitro and the Induction of Delayed-Type Hypersensitivity and Antiviral Activity In Vivo
First Page
35
Last Page
44
Document Type
Article
Publication Date
March 1987
Department
Pathology
Abstract
The properties of two morphologically distinct L3T4+, Lyt2- "helper" T-cell clones specific for herpes simplex virus were investigated. Both of the clones produced IL-3 and interferon, but neither produced IL-2. Clone D6.6 produced macrophage agglutinating factor, a fibronectin-like lymphokine, and also a delayed hypersensitivity (DH) response when injected locally into syngeneic mice. Despite the presence of a DH producing clone and a non-DH producing clone, both were able to reduce the local virus titre to an equivalent degree. It is suggested that this protective activity is associated with the production of interferon-gamma. The significance of these results to mechanisms of protection against herpes simplex virus in vivo is discussed.
Recommended Citation
Seid, M., Leung, K., Pye, C., Phelan, J., Nash, A., & Godfrey, H. (1987). Clonal Analysis of the T-cell Response of Mice to Herpes Simplex Virus: Correlation Between Lymphokine Production In Vitro and the Induction of Delayed-Type Hypersensitivity and Antiviral Activity In Vivo. Viral Immunology, 1 (1), 35-44. https://doi.org/10.1089/vim.1987.1.35
