Lineage Switch From T-Cell Lymphoblastic Leukemia/Lymphoma to Acute Myeloid Leukemia and Back to T-Cell Lymphoblastic Leukemia/Lymphoma in a Patient Diagnosed During Pregnancy

Authors

Amandeep Aujla, New York Medical CollegeFollow
Madhura Hanmantgad, New York Medical College
Humayun Islam, New York Medical CollegeFollow
Fouzia Shakil, New York Medical CollegeFollow
Delong Liu, New York Medical CollegeFollow
Karen Seiter, New York Medical CollegeFollow

DOI

10.21037/sci.2019.05.02

Journal Title

Stem Cell Investigation

First Page

12

Document Type

Case Report

Publication Date

5-1-2019

Department

Pathology, Microbiology and Immunology

Abstract

Although relapse of acute leukemia is common, a change of immunophenotype at relapse only occurs rarely. Some of these cases have been labeled "lineage switch". In most cases, B-cell lymphoblastic leukemia/lymphoma (B-ALL) relapses as acute myeloid leukemia (AML). We report a rare case of T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) relapsing as AML and then returning as T-ALL again in a patient who began her therapy during the third trimester of pregnancy. The patient retained the same cytogenetic and next generation molecular findings in both leukemias. This case provides further evidence of the plasticity of the leukemic stem cell.

Recommended Citation

Aujla, A., Hanmantgad, M., Islam, H., Shakil, F., Liu, D., & Seiter, K. (2019). Lineage Switch From T-Cell Lymphoblastic Leukemia/Lymphoma to Acute Myeloid Leukemia and Back to T-Cell Lymphoblastic Leukemia/Lymphoma in a Patient Diagnosed During Pregnancy. Stem Cell Investigation, 6, 12. https://doi.org/10.21037/sci.2019.05.02