NYMC Faculty Publications

Of Cytometry, Stem Cells and Fountain of Youth

DOI

10.1007/s12015-017-9733-5

Journal Title

Stem Cell Reviews and Reports

First Page

465

Last Page

481

Document Type

Article

Publication Date

8-1-2017

Department

Pathology, Microbiology and Immunology

Abstract

Outlined are advances of cytometry applications to identify and sort stem cells, of laser scanning cytometry and ImageStream imaging instrumentation to further analyze morphometry of these cells, and of mass cytometry to classify a multitude of cellular markers in large cell populations. Reviewed are different types of stem cells, including potential candidates for cancer stem cells, with respect to their "stemness", and other characteristics. Appraised is further progress in identification and isolation of the "very small embryonic-like stem cells" (VSELs) and their autogenous transplantation for tissue repair and geroprotection. Also assessed is a function of hyaluronic acid, the major stem cells niche component, as a guardian and controller of stem cells. Briefly appraised are recent advances and challenges in the application of stem cells in regenerative medicine and oncology and their future role in different disciplines of medicine, including geriatrics.

Publisher's Statement

Originally published in Stem Cell Reviews and Reports, 13 (4), 465-481. The original material can be found here.

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