NYMC Faculty Publications
Long-Term Survivors of Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma
DOI
10.1111/bjh.15775
Journal Title
British Journal of Haematology
First Page
1099
Last Page
1110
Document Type
Article
Publication Date
June 2019
Department
Pediatrics
Abstract
Progress in overall survival rates for childhood non-Hodgkin lymphoma (NHL) can be largely attributed to effective development and conduct of a number of international treatment studies. Knowledge gained from these studies has shifted the treatment paradigm from a "one-size fits all" strategy to a histologically dependent approach. More specifically, many now adhere to a risk-stratified approach, prescribing cumulative doses and intensities of chemotherapeutic exposures based upon the aggressiveness of disease. Moreover, recognition that high cure rates could be achieved without the use of radiation has eliminated the use of this modality in frontline settings for the majority of newly diagnosed children. These changes have contributed to the emergence of a heterogeneous group of NHL survivors. As the number of NHL survivors continues to increase, providers will encounter a wide spectrum of individuals whose risk for long-term complications are accordingly diverse. The following review summarizes the existing literature surrounding late effects, such as chronic health conditions, functional and neurocognitive performance outcomes, and health-related quality of life, that are unique to NHL survivors, as well as those extrapolated from the broader childhood cancer survivor population.
Recommended Citation
Ehrhardt, M., Hochberg, J., Bjornard, K., & Brinkman, T. (2019). Long-Term Survivors of Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma. British Journal of Haematology, 185 (6), 1099-1110. https://doi.org/10.1111/bjh.15775