Passive Drainage to Gravity and Closed-Suction Drainage Following Pancreatoduodenectomy Lead to Similar Grade B and C Postoperative Pancreatic Fistula Rates. A Meta-Analysis

Authors

Mahir Gachabayov, New York Medical College
Shekhar Gogna, New York Medical College
Rifat Latifi, New York Medical CollegeFollow
Xiang D. Dong, New York Medical CollegeFollow

DOI

10.1016/j.ijsu.2019.05.001

Journal Title

International Journal of Surgery

First Page

24

Last Page

31

Document Type

Article

Publication Date

July 2019

Department

Surgery

Keywords

Drain, Pancreatic fistula, Pancreatic surgery, Pancreatoduodenectomy, Whipple procedure

Disciplines

Medicine and Health Sciences

Abstract

INTRODUCTION: There is no level 1a evidence regarding the impact of passive drainage to gravity (PDG) and closed-suction drainage (CSD) following pancreatoduodenectomy on clinical outcomes. The aim of this meta-analysis was to evaluate the impact of PDG versus CSD on surgical outcomes following pancreaticoduodenectomy in high risk patients who would benefit from pancreatic drainage. METHODS: The Pubmed, EMBASE, and Cochrane Library were systematically searched. Postoperative pancreatic fistula (POPF) rate was the primary endpoint. A subgroup meta-analysis of randomized controlled trials (RCT) was performed in addition to a meta-analysis of all eligible studies. Mantel-Haenszel method (random-effects model) with odds ratios and 95% confidence intervals (OR (95%CI)) as an effect measure was utilized. RESULTS: Six studies, whereof 3 RCTs, involving 1519 patients (806 PDG and 713 CSD) were included. In meta-analysis of all studies, overall [OR (95%CI)=0.81 (0.42, 1.56); p=0.53; I(2)=79%; Tau(2)=0.54]; grade A [OR (95%CI)=0.71 (0.33, 1.53); p=0.39; I(2)=65%; Tau(2)=0.47]; grade B [OR (95%CI)=1.23 (0.74, 2.05); p=0.42; I(2)=0%]; and grade C [OR (95%CI)=1.08 (0.56, 2.09); p=0.82; I(2)=5%] POPF rates did not differ. Subgroup analysis of RCTs confirmed the finding that grade B and C POPF rates did not significantly differ with low heterogeneity [OR (95%CI)=1.55 (0.79, 3.04); p=0.20; I(2)=0%]. No publication bias was found (t=0.48; p=0.64). CONCLUSION: This meta-analysis found no difference in short-term clinical outcomes including, clinically relevant, grade B and C POPF rates between PDG and CSD. Furthermore, postoperative complication rates were similar with the use of either drain.

Recommended Citation

Gachabayov, M., Gogna, S., Latifi, R., & Dong, X. (2019). Passive Drainage to Gravity and Closed-Suction Drainage Following Pancreatoduodenectomy Lead to Similar Grade B and C Postoperative Pancreatic Fistula Rates. A Meta-Analysis. International Journal of Surgery, 67, 24-31. https://doi.org/10.1016/j.ijsu.2019.05.001