Synthetically Modified Methoxsalen for Enhanced Cytotoxicity in Light and Dark Reactions

Authors

Christophe Guillon
Yi-Hua Jan
Natalie Foster
Joel Ressner
Diane E. Heck, New York Medical CollegeFollow
Jeffrey D. Laskin, New York Medical College
Ned D. Heindel

DOI

10.1016/j.bmcl.2018.12.048

Journal Title

Bioorganic & Medicinal Chemistry Letters

First Page

619

Last Page

622

Document Type

Article

Publication Date

2-1-2019

Department

Environmental Health Science

Keywords

8-MOP, 8-Methoxypsoralen, Dark-reaction toxicity, Keratinocytes, PAM212, Phototoxicity

Disciplines

Medicine and Health Sciences

Abstract

Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.

Recommended Citation

Guillon, C., Jan, Y., Foster, N., Ressner, J., Heck, D., Laskin, J., & Heindel, N. (2019). Synthetically Modified Methoxsalen for Enhanced Cytotoxicity in Light and Dark Reactions. Bioorganic & Medicinal Chemistry Letters, 29 (4), 619-622. https://doi.org/10.1016/j.bmcl.2018.12.048