NYMC Faculty Publications
Synthetically Modified Methoxsalen for Enhanced Cytotoxicity in Light and Dark Reactions
Journal Title
Bioorganic & Medicinal Chemistry Letters
First Page
619
Last Page
622
Document Type
Article
Publication Date
2-1-2019
Department
Environmental Health Science
Abstract
Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.
Recommended Citation
Guillon, C., Jan, Y., Foster, N., Ressner, J., Heck, D., Laskin, J., & Heindel, N. (2019). Synthetically Modified Methoxsalen for Enhanced Cytotoxicity in Light and Dark Reactions. Bioorganic & Medicinal Chemistry Letters, 29 (4), 619-622. https://doi.org/10.1016/j.bmcl.2018.12.048
