NYMC Faculty Publications
Hypertension-Induced Enhanced Myogenic Constriction of Cerebral Arteries Is Preserved after Traumatic Brain Injury
DOI
10.1089/neu.2016.4962
Journal Title
Journal of Neurotrauma
First Page
2315
Last Page
2319
Document Type
Article
Publication Date
7-15-2017
Department
Physiology
Abstract
Traumatic brain injury (TBI) was shown to impair pressure-induced myogenic response of cerebral arteries, which is associated with vascular and neural dysfunction and increased mortality of TBI patients. Hypertension was shown to enhance myogenic tone of cerebral arteries via increased vascular production of 20-hydroxyeicosatrienoic acid (HETE). This adaptive mechanism protects brain tissue from pressure/volume overload; however, it can also lead to increased susceptibility to cerebral ischemia. Although both effects may potentiate the detrimental vascular consequences of TBI, it is not known how hypertension modulates the effect of TBI on myogenic responses of cerebral vessels. We hypothesized that in hypertensive rats, the enhanced myogenic cerebrovascular response is preserved after TBI. Therefore, we investigated the myogenic responses of isolated middle cerebral arteries (MCA) of normotensive and spontaneously hypertensive rats (SHR) after severe impact acceleration diffuse brain injury. TBI diminished myogenic constriction of MCAs isolated from normotensive rats, whereas the 20-HETE-mediated enhanced myogenic response of MCAs isolated from SHRs was not affected by TBI. These results suggest that the optimal cerebral perfusion pressure values and vascular signaling pathways can be different and, therefore, should be targeted differently in normotensive and hypertensive patients following TBI.
Recommended Citation
Szarka, N., Amrein, K., Horvath, P., Ivic, I., Czeiter, E., Koller, A., & Toth, P. (2017). Hypertension-Induced Enhanced Myogenic Constriction of Cerebral Arteries Is Preserved after Traumatic Brain Injury. Journal of Neurotrauma, 34 (14), 2315-2319. https://doi.org/10.1089/neu.2016.4962
Publisher's Statement
Originally published in Journal of Neurotrauma, 34 (14), 2315-2319. The original material can be found here.
Comments
Please see the work itself for the complete list of authors.