NYMC Faculty Publications
Mechanisms of DNA-Reactive and Epigenetic Chemical Carcinogens: Applications to Carcinogenicity Testing and Risk Assessment
DOI
10.1039/c8tx00250a
Journal Title
Toxicology Research
First Page
123
Last Page
145
Document Type
Article
Publication Date
March 2019
Department
Pathology, Microbiology and Immunology
Abstract
Chemicals with carcinogenic activity in either animals or humans produce increases in neoplasia through diverse mechanisms. One mechanism is reaction with nuclear DNA. Other mechanisms consist of epigenetic effects involving either modifications of regulatory macromolecules or perturbation of cellular regulatory processes. The basis for distinguishing between carcinogens that have either DNA reactivity or an epigenetic activity as their primary mechanism of action is detailed in this review. In addition, important applications of information on these mechanisms of action to carcinogenicity testing and human risk assessment are discussed.
Recommended Citation
Kobets, T., Iatropoulos, M., & Williams, G. (2019). Mechanisms of DNA-Reactive and Epigenetic Chemical Carcinogens: Applications to Carcinogenicity Testing and Risk Assessment. Toxicology Research, 8 (2), 123-145. https://doi.org/10.1039/c8tx00250a