NYMC Faculty Publications
Dysregulated Mineral Metabolism in AKI
Journal Title
Seminars in Nephrology
First Page
41
Last Page
56
Document Type
Article
Publication Date
January 2019
Department
Medicine
Abstract
Dysregulated mineral metabolism is a nearly universal sequalae of acute kidney injury (AKI). Abnormalities in circulating mineral metabolites observed in patients with AKI include hypocalcemia, hyperparathyroidism, hyperphosphatemia, decreased vitamin D metabolite levels, and increased fibroblast growth factor 23 levels. We review the pathophysiology of dysregulated mineral metabolism in AKI with a focus on calcium, phosphate, parathyroid hormone, and vitamin D metabolites. We discuss how mineral metabolite levels can serve as novel prognostic markers for incident AKI and other related outcomes in various clinical settings. Finally, we discuss how vitamin D metabolites potentially could be used as novel therapeutic agents for AKI prevention and treatment.
Recommended Citation
Leaf, D. E., & Christov, M. (2019). Dysregulated Mineral Metabolism in AKI. Seminars in Nephrology, 39 (1), 41-56. https://doi.org/10.1016/j.semnephrol.2018.10.004
