Dysregulated Mineral Metabolism in AKI

Authors

David E. Leaf
Marta Christov, New York Medical CollegeFollow

DOI

10.1016/j.semnephrol.2018.10.004

Journal Title

Seminars in Nephrology

First Page

41

Last Page

56

Document Type

Article

Publication Date

January 2019

Department

Medicine

Keywords

AKI;FGF23, PTH, acute kidney injury, calcium, mineral metabolism, phosphate, vitamin D

Disciplines

Medicine and Health Sciences

Abstract

Dysregulated mineral metabolism is a nearly universal sequalae of acute kidney injury (AKI). Abnormalities in circulating mineral metabolites observed in patients with AKI include hypocalcemia, hyperparathyroidism, hyperphosphatemia, decreased vitamin D metabolite levels, and increased fibroblast growth factor 23 levels. We review the pathophysiology of dysregulated mineral metabolism in AKI with a focus on calcium, phosphate, parathyroid hormone, and vitamin D metabolites. We discuss how mineral metabolite levels can serve as novel prognostic markers for incident AKI and other related outcomes in various clinical settings. Finally, we discuss how vitamin D metabolites potentially could be used as novel therapeutic agents for AKI prevention and treatment.

Recommended Citation

Leaf, D. E., & Christov, M. (2019). Dysregulated Mineral Metabolism in AKI. Seminars in Nephrology, 39 (1), 41-56. https://doi.org/10.1016/j.semnephrol.2018.10.004