NYMC Faculty Publications

Genetic Approaches to Bronchopulmonary Dysplasia

DOI

10.1542/neo.20-5-e272

Journal Title

NeoReviews

First Page

e272

Last Page

e279

Document Type

Article

Publication Date

May 2019

Department

Pediatrics

Abstract

Bronchopulmonary dysplasia (BPD) remains a common and challenging complication of prematurity, with limited effective strategies at the neonatologist's disposal. Throughout the years, our understanding of this complex syndrome has broadened. Instead of solely attributing this disease to the effects of prematurity and injuries to the lung from mechanical ventilation, it is now accepted to be a multifactorial disease. Recent research efforts have focused on investigating the gene-environment interactions that may influence an infant's susceptibility toward the development of BPD. So far, success has been limited but promising, offering hope that in the future, novel therapies will be available to ameliorate the risk for BPD.

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