Assessment of DNA Binding and Oxidative DNA Damage by Acrylonitrile in Two Rat Target Tissues of Carcinogenicity: Implications for the Mechanism of Action

Authors

Gary M. Williams, New York Medical CollegeFollow
Tetyana Kobets, New York Medical CollegeFollow
Jian Dong Duan, New York Medical CollegeFollow
Michael J. Iatropoulos, New York Medical CollegeFollow

DOI

10.1021/acs.chemrestox.7b00105

Journal Title

Chemical Research in Toxicology

First Page

1470

Last Page

1480

Document Type

Article

Publication Date

7-17-2017

Department

Pathology, Microbiology and Immunology

Abstract

Exposure to acrylonitrile induces formation of tumors at multiple sites in rats, with females being more sensitive. The present study assessed possible mechanisms of acrylonitrile tumorigenicity, covalent DNA binding, DNA breakage, and oxidative DNA damage, in two target tissues, the brain and Zymbal's glands, of sensitive female Fischer (F344) and Sprague-Dawley (SD) rats. One group received acrylonitrile in drinking water at 100 ppm for 28 days. Two other groups were administered either acrylonitrile in drinking water at 100 ppm or drinking water alone for 27 days, followed by a single oral gavage dose of 11 mg/kg bw

Recommended Citation

Williams, G. M., Kobets, T., Duan, J., & Iatropoulos, M. J. (2017). Assessment of DNA Binding and Oxidative DNA Damage by Acrylonitrile in Two Rat Target Tissues of Carcinogenicity: Implications for the Mechanism of Action. Chemical Research in Toxicology, 30 (7), 1470-1480. https://doi.org/10.1021/acs.chemrestox.7b00105

Publisher's Statement

Originally published in Chemical Research in Toxicology, 30 (7), 1470-1480. The original material can be found here.