NYMC Faculty Publications
Nucleolin Is a Functional Binding Protein for Salinomycin in Neuroblastoma Stem Cells
Journal Title
Journal of the American Chemical Society
First Page
3613
Last Page
3622
Document Type
Article
Publication Date
February 2019
Department
Biochemistry and Molecular Biology
Abstract
The aim of this study is to illuminate a novel therapeutic approach by identifying a functional binding target of salinomycin, an emerging anticancer stem cell (CSC) agent, and to help dissect the underlying action mechanisms. By utilizing integrated strategies, we identify that nucleolin (NCL) is likely a salinomycin-binding target and a critical regulator involved in human neuroblastoma (NB) CSC activity. Salinomycin markedly suppresses NB CD34 expression and reduces CD34+ cell population in an NCL-dependent manner via disruption of the interaction of NCL with CD34 promoter. The elevated levels of NCL expression in NB tumors are associated with poor patient survival. Altogether, these results indicate that NCL is likely a novel functional salinomycin-binding target that exhibits the potential to be a prognostic marker for NB therapy.
Recommended Citation
Wang, F., Zhou, S., Qi, D., Xiang, S., Wong, E., Wang, X., Fonkem, E., Hsieh, T., Yang, J., Kirmani, B., Shabb, J., Wu, J., Wu, M., Huang, J., Yu, W., & Wu, E. (2019). Nucleolin Is a Functional Binding Protein for Salinomycin in Neuroblastoma Stem Cells. Journal of the American Chemical Society, 141 (8), 3613-3622. https://doi.org/10.1021/jacs.8b12872
