NYMC Faculty Publications

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NYMC First Author with a 2018 publication with the highest number of downloads in Touro Scholar at 2019 NYMC Faculty Author Celebration

DOI

10.1016/j.neubiorev.2017.07.009

Journal Title

Neuroscience and Biobehavioral Reviews

First Page

21

Last Page

33

Document Type

Article

Publication Date

2-1-2018

Department

Physiology

Abstract

An array of neuromodulators, including monoamines and neuropeptides, regulate most behavioural and physiological traits. In the past decade, dramatic progress has been made in mapping neuromodulatory circuits, in analysing circuit dynamics, and interrogating circuit function using pharmacogenetic, optogenetic and imaging methods This review will focus on several distinct neural networks (acetylcholine/GABA/glutamate; histamine/GABA; orexin/glutamate; and relaxin-3/GABA) that originate from neural hubs that regulate wakefulness and related attentional and cognitive processes, and highlight approaches that have identified dual transmitter roles in these behavioural functions. Modulation of these different neural networks might be effective treatments of diseases related to arousal/sleep dysfunction and of cognitive dysfunction in psychiatric and neurodegenerative disorders.

Publisher's Statement

This is the author's accepted manuscript. The Version of Record can be found at https://doi.org/10.1016/j.neubiorev.2017.07.009

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