Lack of Efficacy of Ivermectin for Pevention of a Lethal Zika virus Infection in a Murine System

Authors

Harshada Ketkar, New York Medical College
Long Yang, New York Medical College
Gary P. Wormser, New York Medical CollegeFollow
Penghua Wang

DOI

10.1016/j.diagmicrobio.2019.03.012

Journal Title

Diagnostic Microbiology and Infectious Disease

Document Type

Article

Publication Date

March 2019

Department

Medicine

Keywords

Ivermectin, Mouse model, Zika virus

Disciplines

Medicine and Health Sciences

Abstract

The antihelminthic drug ivermectin has been demonstrated to have antiviral activity against the Zika virus and other arboviruses in in vitro studies. The effectiveness of ivermectin for Zika virus infection, however, has never been studied in an animal model. In this study, ivermectin was found to be ineffective for prevention of a lethal infection with the Senegal strain of Zika virus in Ifnar1 knockout mice. In view of several study limitations, evaluation of ivermectin's anti-Zika virus activity in other animal models and against other Zika virus strains would be desirable.

Recommended Citation

Ketkar, H., Yang, L., Wormser, G., & Wang, P. (2019). Lack of Efficacy of Ivermectin for Pevention of a Lethal Zika virus Infection in a Murine System. Diagnostic Microbiology and Infectious Disease. https://doi.org/10.1016/j.diagmicrobio.2019.03.012