NYMC Faculty Publications
DOI
10.1074/jbc.M116.767178
Journal Title
Journal of Biological Chemistry
First Page
11431
Last Page
11444
Document Type
Article
Publication Date
7-7-2017
Department
Pathology, Microbiology and Immunology
Abstract
Elevated cellular response to hypoxia, which contributes to cell transformation and tumor progression, is a prominent feature of malignant cells in solid tumors. Polo-like kinase 3 (Plk3) is a serine/threonine protein kinase known to inhibit the cellular response to hypoxia and tumorigenesis. Nickel compounds are well-established human carcinogens that induce tumorigenesis partly through their hypoxia-mimicking effects. Despite previous research efforts, the role of Plk3 in the hypoxic response induced by hypoxia or nickel is not completely understood. Here, we show that NiCl
Recommended Citation
Li, C., Park, S., Zhang, X., Dai, W., & Xu, D. (2017). Mutual Regulation Between Polo-like Kinase 3 and SIAH2 E3 Ubiquitin Ligase Defines a Regulatory Network That Fine-tunes the Cellular Response to Hypoxia and Nickel. Journal of Biological Chemistry, 292 (27), 11431-11444. https://doi.org/10.1074/jbc.M116.767178
Publisher's Statement
This research was originally published in the Journal of Biological Chemistry. Li, C., Park, S., Zhang, X., Dai, W., & Xu, D. (2017). Mutual Regulation Between Polo-like Kinase 3 and SIAH2 E3 Ubiquitin Ligase Defines a Regulatory Network That Fine-tunes the Cellular Response to Hypoxia and Nickel. Journal of Biological Chemistry, 292 (27), 11431-11444. doi:10.1074/jbc.M116.767178 © the American Society for Biochemistry and Molecular Biology.
