Mutual Regulation Between Polo-like Kinase 3 and SIAH2 E3 Ubiquitin Ligase Defines a Regulatory Network That Fine-tunes the Cellular Response to Hypoxia and Nickel

Authors

Cen Li
Soyoung Park
Xiaowen Zhang
Wei Dai
Dazhong Xu, New York Medical CollegeFollow

Journal Title

Journal of Biological Chemistry

First Page

11431

Last Page

11444

Document Type

Article

Publication Date

7-7-2017

Department

Pathology, Microbiology and Immunology

Abstract

Elevated cellular response to hypoxia, which contributes to cell transformation and tumor progression, is a prominent feature of malignant cells in solid tumors. Polo-like kinase 3 (Plk3) is a serine/threonine protein kinase known to inhibit the cellular response to hypoxia and tumorigenesis. Nickel compounds are well-established human carcinogens that induce tumorigenesis partly through their hypoxia-mimicking effects. Despite previous research efforts, the role of Plk3 in the hypoxic response induced by hypoxia or nickel is not completely understood. Here, we show that NiCl

Recommended Citation

Li, C., Park, S., Zhang, X., Dai, W., & Xu, D. (2017). Mutual Regulation Between Polo-like Kinase 3 and SIAH2 E3 Ubiquitin Ligase Defines a Regulatory Network That Fine-tunes the Cellular Response to Hypoxia and Nickel. Journal of Biological Chemistry, 292 (27), 11431-11444. https://doi.org/10.1074/jbc.M116.767178

Publisher's Statement

This research was originally published in the Journal of Biological Chemistry. Li, C., Park, S., Zhang, X., Dai, W., & Xu, D. (2017). Mutual Regulation Between Polo-like Kinase 3 and SIAH2 E3 Ubiquitin Ligase Defines a Regulatory Network That Fine-tunes the Cellular Response to Hypoxia and Nickel. Journal of Biological Chemistry, 292 (27), 11431-11444. doi:10.1074/jbc.M116.767178 © the American Society for Biochemistry and Molecular Biology.