NYMC Faculty Publications
Kir4.1/5.1 in the DCT Plays a Role in the Regulation of Renal K+ Excretion
DOI
10.1152/ajprenal.00412.2018
Journal Title
American Journal of Physiology.Renal Physiology
First Page
F582
Last Page
F586
Document Type
Article
Publication Date
January 2019
Department
Pharmacology
Keywords
K excretion;NCC, NKCC2, distal convoluted tubule
Disciplines
Medicine and Health Sciences
Abstract
The aim of this mini review is to provide an overview regarding the role of inwardly-rectifying potassium channel 4.1 (Kir4.1)/Kir5.1 in regulating renal K(+) excretion. Deletion of Kir4.1 in the kidney inhibited thiazide-sensitive NaCl cotransporter (NCC) activity in the distal convoluted tubule (DCT) and slightly suppressed Na-K-2Cl cotransporter (NKCC2) function in the thick ascending limb (TAL). Moreover, increased dietary K(+) intake inhibited, whereas decreased dietary K(+) intake stimulated, the basolateral potassium channel (a Kir4.1/Kir5.1 heterotetramer) in the DCT. The alteration of the basolateral potassium conductance is essential for the effect of dietary K(+) intake on NCC because deletion of Kir4.1 in the DCT abolished the effect of dietary K(+) intake on NCC. Since potassium-intake-mediated regulation of NCC plays a key role in regulating renal K(+) excretion and potassium homeostasis, the deletion of Kir4.1 caused severe hypokalemia and metabolic alkalosis under control conditions and even during increased dietary K(+) intake. Finally, recent studies have suggested that angiotensin II type 2 receptor (AT2R) and bradykinin-B2 receptor (BK2R) are involved in mediating the effect of high dietary K(+) intake on Kir4.1/Kir5.1 in the DCT.
Recommended Citation
Su, X., Ellison, D., & Wang, W. (2019). Kir4.1/5.1 in the DCT Plays a Role in the Regulation of Renal K+ Excretion. American Journal of Physiology.Renal Physiology, 316 (3), F582-F586. https://doi.org/10.1152/ajprenal.00412.2018
