NYMC Faculty Publications
HO-1 Overexpression and Underexpression: Clinical Implications
DOI
10.1016/j.abb.2019.108073
Journal Title
Archives of Biochemistry and Biophysics
First Page
108073
Document Type
Article
Publication Date
August 2019
Department
Medicine
Abstract
In this review we examine the effects of both over- and under-production of heme oxygenase-1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular disease. In a few instances e.g., neonatal jaundice, overproduction of HO-1 and increased HO activity results in elevated levels of bilirubin requiring clinical intervention with inhibitors of HO activity. In contrast HO-1 levels and HO activity are low in obesity and the HO system responds to mitigate the deleterious effects of oxidative stress through increased levels of bilirubin (anti-inflammatory) and CO (anti-apoptotic) and decreased levels of heme (pro-oxidant). Site specific HO-1 overexpression diminishes adipocyte terminal differentiation and lipid accumulation of obesity mediated release of inflammatory molecules. A series of diverse strategies have been implemented that focus on increasing HO-1 and HO activity that are central to reversing the clinical complications associated with diseases including, obesity, metabolic syndrome and vascular disease.
Recommended Citation
Drummond, G., Baum, J., Greenberg, M., Lewis, D., & Abraham, N. (2019). HO-1 Overexpression and Underexpression: Clinical Implications. Archives of Biochemistry and Biophysics, 673, 108073. https://doi.org/10.1016/j.abb.2019.108073
