NYMC Faculty Publications
Intrahepatic Upregulation of MRTF-A Signaling Contributes to Increased Hepatic Vascular Resistance in Cirrhotic Rats With Portal Hypertension
Journal Title
Clinics and Research in Hepatology and Gastroenterology
First Page
303
Last Page
310
Document Type
Article
Publication Date
6-1-2017
Department
Physiology
Abstract
BACKGROUND: Portal hypertension in cirrhosis is mediated, in part, by increased intrahepatic resistance, reflecting massive structural changes associated with fibrosis and intrahepatic vasoconstriction. Activation of the Rho/MRTF/SRF signaling pathway is essential for the cellular regulatory network of fibrogenesis. The aim of this study was to investigate MRTF-A-mediated regulation of intrahepatic fibrogenesis in cirrhotic rats.
METHODS: Portal hypertension was induced in rats via an injection of CCl
RESULTS: Upregulation of MRTF-A protein expression in the livers of rats with CCl
CONCLUSION: Increased intrahepatic resistance in rats with CCl
Recommended Citation
Zheng, L., Qin, J., Sun, L., Gui, L., Huang, A., Sun, D., & Luo, M. (2017). Intrahepatic Upregulation of MRTF-A Signaling Contributes to Increased Hepatic Vascular Resistance in Cirrhotic Rats With Portal Hypertension. Clinics and Research in Hepatology and Gastroenterology, 41 (3), 303-310. https://doi.org/10.1016/j.clinre.2016.11.010
Publisher's Statement
Originally published in Clinics and Research in Hepatology and Gastroenterology, 41 (3), 303-310. The original material can be found here.
Comments
Please see the work itself for the complete list of authors.