Intrahepatic Upregulation of MRTF-A Signaling Contributes to Increased Hepatic Vascular Resistance in Cirrhotic Rats With Portal Hypertension

Authors

Lei Zheng
Jun Qin
Longci Sun
Liang Gui
An Huang, New York Medical CollegeFollow
Dong Sun, New York Medical CollegeFollow
Meng Luo

Journal Title

Clinics and Research in Hepatology and Gastroenterology

First Page

303

Last Page

310

Document Type

Article

Publication Date

6-1-2017

Department

Physiology

Abstract

BACKGROUND: Portal hypertension in cirrhosis is mediated, in part, by increased intrahepatic resistance, reflecting massive structural changes associated with fibrosis and intrahepatic vasoconstriction. Activation of the Rho/MRTF/SRF signaling pathway is essential for the cellular regulatory network of fibrogenesis. The aim of this study was to investigate MRTF-A-mediated regulation of intrahepatic fibrogenesis in cirrhotic rats.

METHODS: Portal hypertension was induced in rats via an injection of CCl

RESULTS: Upregulation of MRTF-A protein expression in the livers of rats with CCl

CONCLUSION: Increased intrahepatic resistance in rats with CCl

Comments

Please see the work itself for the complete list of authors.

Recommended Citation

Zheng, L., Qin, J., Sun, L., Gui, L., Huang, A., Sun, D., & Luo, M. (2017). Intrahepatic Upregulation of MRTF-A Signaling Contributes to Increased Hepatic Vascular Resistance in Cirrhotic Rats With Portal Hypertension. Clinics and Research in Hepatology and Gastroenterology, 41 (3), 303-310. https://doi.org/10.1016/j.clinre.2016.11.010

Publisher's Statement

Originally published in Clinics and Research in Hepatology and Gastroenterology, 41 (3), 303-310. The original material can be found here.