Intestinal Pathophysiological and Microbial Changes in Sickle Cell Disease: Potential Targets for Therapeutic Intervention

Authors

Dibyendu Dutta, New York Medical CollegeFollow
Amandeep Aujla, New York Medical CollegeFollow
Bettina M. Knoll, New York Medical CollegeFollow
Seah H. Lim, New York Medical CollegeFollow

DOI

10.1111/bjh.16273

Journal Title

British Journal of Haematology

Document Type

Article

Publication Date

November 2019

Department

Medicine

Abstract

There is a large therapeutic gap in the treatment of sickle cell disease (SCD). Recent studies demonstrated the presence of pathophysiological and microbial changes in the intestine of patients with SCD. The intestinal microbes have also been found to regulate neutrophil ageing and possible basal activation of circulating neutrophils. Both aged and activated neutrophils are pivotal for the pathogenesis of vaso-occlusive crisis in SCD. In this paper, we will provide an overview of the intestinal pathophysiological and microbial changes in SCD. Based on these changes, we will propose therapeutic approaches that could be investigated for treating SCD.

Recommended Citation

Dutta, D., Aujla, A., Knoll, B., & Lim, S. (2019). Intestinal Pathophysiological and Microbial Changes in Sickle Cell Disease: Potential Targets for Therapeutic Intervention. British Journal of Haematology. https://doi.org/10.1111/bjh.16273