Immunotherapeutic Challenges for Pediatric Cancers

Authors

Brian Hutzen
Mohammed Ghonime
Joel Lee
Elaine R. Mardis
Ruoning Wang
Dean A. LeeFollow
Mitchell S. Cairo, New York Medical CollegeFollow
Ryan D. Roberts
Timothy P. Cripe
Kevin A. Cassady

DOI

10.1016/j.omto.2019.08.005

Journal Title

Molecular Therapy Oncolytics

First Page

38

Last Page

48

Document Type

Article

Publication Date

December 2019

Department

Pediatrics

Abstract

Solid tumors contain a mixture of malignant cells and non-malignant infiltrating cells that often create a chronic inflammatory and immunosuppressive microenvironment that restricts immunotherapeutic approaches. Although childhood and adult cancers share some similarities related to microenvironmental changes, pediatric cancers are unique, and adult cancer practices may not be wholly applicable to our pediatric patients. This review highlights the differences in tumorigenesis, viral infection, and immunologic response between children and adults that need to be considered when trying to apply experiences from experimental therapies in adult cancer patients to pediatric cancers.

Recommended Citation

Hutzen, B., Ghonime, M., Lee, J., Mardis, E., Wang, R., Lee, D., Cairo, M., Roberts, R., Cripe, T., & Cassady, K. (2019). Immunotherapeutic Challenges for Pediatric Cancers. Molecular Therapy Oncolytics, 15, 38-48. https://doi.org/10.1016/j.omto.2019.08.005