NYMC Faculty Publications
Gemtuzumab Ozogamicin and Novel Antibody-Drug Conjugates in Clinical Trials for Acute Myeloid Leukemia
DOI
10.1186/s40364-019-0175-x
Journal Title
Biomarker Research
First Page
24
Document Type
Article
Publication Date
October 2019
Department
Medicine
Abstract
Targeted agents are increasingly used for the therapy of acute myeloid leukemia (AML). Gemtuzumab ozogamicin (GO) is the first antibody-drug conjugate (ADC) approved for induction therapy of AML. When used in fractionated doses, GO combined with the conventional cytarabine/anthracycline-based induction chemotherapy significantly improves the outcome of previously untreated AML patients. Single-agent GO is effective and safe for AML patient ineligible for intensive chemotherapy. Multiple combination regimens incorporating GO have also been recommended as potential alternative options. In addition, several novel ADCs targeting CD33, CD123 and CLL-1 are currently undergoing preclinical or early clinical investigations. In this review, we summarized the efficacy and limitations of GO as well as novel ADCs for adult AML patients.
Recommended Citation
Yu, B., & Liu, D. (2019). Gemtuzumab Ozogamicin and Novel Antibody-Drug Conjugates in Clinical Trials for Acute Myeloid Leukemia. Biomarker Research, 7, 24. https://doi.org/10.1186/s40364-019-0175-x
