NYMC Faculty Publications
Primary Effusion Lymphoma of the Pleural Space: Report of a Rare Complication of Cardiac Transplant with Review of the Literature
DOI
10.1111/tid.13005
Journal Title
Transplant Infectious Disease
First Page
e13005
Document Type
Case Report
Publication Date
February 2019
Department
Pathology, Microbiology and Immunology
Keywords
Diagnosis, Differential, Heart Transplantation, Herpesvirus 8, Human, Immunosuppression, Lymphoma, Primary Effusion, Neoplasm Recurrence, Local, Pleural Cavity, Postoperative Complications, Sarcoma, Kaposi, Skin Neoplasms , Viremia, heart transplant, human herpesvirus-8, pleural effusion, primary effusion lymphomaLR: 20190405; CI: (c) 2018; JID: 100883688; OTO: NOTNLM; 2018/07/16 00:00 [received]; 2018/09/01 00:00 [revised]; 2018/09/10 00:00 [accepted]; 2018/10/03 06:00 [pubmed]; 2019/04/06 06:00 [medline]; 2018/10/03 06:00 [entrez]; ppublish
Disciplines
Medicine and Health Sciences
Abstract
Primary effusion lymphoma (PEL) is a rare mature B-cell non-Hodgkin's lymphoma arising in body cavities and presenting with effusions. It has been described predominantly in patients with impaired immunity from the acquired immunodeficiency syndrome and is associated with the Human Herpesvirus-8 (HHV-8). Seldom has PEL been diagnosed in persons negative for the human immunodeficiency virus (HIV), and in such cases it has occurred primarily in the setting of posttransplant immunosuppression. We report an instructive case of a Caribbean-American HIV-negative orthotopic heart transplant recipient with a history of HHV-8-associated Kaposi's sarcoma who developed HHV-8 viremia and PEL of the pleural space early in the posttransplant course. This case highlights the importance of considering PEL in the differential diagnosis of a new pleural effusion in a transplant recipient at risk for HHV-8-associated disease.
Recommended Citation
Kugasia, I., Kumar, A., Khatri, A., Saeed, F., Islam, H., & Epelbaum, O. (2019). Primary Effusion Lymphoma of the Pleural Space: Report of a Rare Complication of Cardiac Transplant with Review of the Literature. Transplant Infectious Disease, 21 (1), e13005. https://doi.org/10.1111/tid.13005
