NYMC Faculty Publications
"Are We There Yet?" Quest for Treatment of Refractory Epilepsy
DOI
10.1177/1535759718822843
Journal Title
Epilepsy Currents
First Page
57
Last Page
58
Document Type
Response or Comment
Publication Date
1-1-2019
Department
Cell Biology and Anatomy
Abstract
Biochemical Autoregulatory Gene Therapy for Focal Epilepsy Lieb A, Qiu Y, Dixon CL, Heller JP, Walker MC, Schorge S, Kullmann DM. Nat Med. 2018;24:1324-1329. Despite the introduction of more than one dozen new antiepileptic drugs in the past 20 years, approximately one-third of people who develop epilepsy continue to have seizures on mono- or polytherapy. Viral-vector-mediated gene transfer offers the opportunity to design a rational treatment that builds on mechanistic understanding of seizure generation and that can be targeted to specific neuronal populations in epileptogenic foci. Several such strategies have shown encouraging results in different animal models, although clinical translation is limited by possible effects on circuits underlying cognitive, mnemonic, sensory, or motor function. Here, we describe an autoregulatory antiepileptic gene therapy, which relies on neuronal inhibition in response to elevations in extracellular glutamate. It is effective in a rodent model of focal epilepsy and is well tolerated, thus lowering the barrier to clinical translation.
Recommended Citation
Velisek, L. (2019). "Are We There Yet?" Quest for Treatment of Refractory Epilepsy. Epilepsy Currents, 19 (1), 57-58. https://doi.org/10.1177/1535759718822843